Search results for " perirhinal cortex"
showing 3 items of 3 documents
Recollection and familiarity in dense hippocampal amnesia: A case study
2004
In the amnesia literature, disagreement exists over whether anterograde amnesia involves recollective-based recognition processes and/or familiarity-based ones depending on whether the anatomical damage is restricted to the hippocampus or also involves adjacent areas, particularly the entorhinal and perirhinal cortices. So far, few patients with well documented anatomical lesions and detailed assessment of recollective and recognition performance have been described. We report a comprehensive neuroanatomical assessment and detailed investigation of the anterograde memory functions of a previously described severe amnesic patient (VC). The results of four previously published neuroradiologic…
The role of neurosteoids sulphate in a spatial and object recognition learning task
2012
The term “neuroactive steroid” refers to steroids that have rapid modulatory effects on ligand-gated ion channels via non-genomic mechanism. Specifically, neurosteroids can alter neuronal excitability via the cell surface interacting with specific neurotransmitter receptors. The neurosteroid pregnenolone sulphate (PREGS) has been described as negative modulator of GABAA receptor and positive modulator of NMDA receptor, affecting cognition as well as emotionality. The present study was aimed to assess the effects of the acute administration of PREGS (10 mg/Kg, s. c.) on rats cognitive functions using a novel task, the Can test. This task explores, under reinforcement, the spatial/visual cues…
Pregnenolone sulphate enhances spatial orientation and object discrimination in adult male rats: Evidence from a behavioural and electrophysiological…
2013
Abstract Neurosteroids can alter neuronal excitability interacting with specific neurotransmitter receptors, thus affecting several functions such as cognition and emotionality. In this study we investigated, in adult male rats, the effects of the acute administration of pregnenolone-sulfate (PREGS) (10 mg/kg, s.c.) on cognitive processes using the Can test, a non aversive spatial/visual task which allows the assessment of both spatial orientation–acquisition and object discrimination in a simple and in a complex version of the visual task. Electrophysiological recordings were also performed in vivo , after acute PREGS systemic administration in order to investigate on the neuronal activati…